Using niacinamide and ceramide together: 5 reasons you should mix it


Updated: 6 April 2024

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Using Niacinamide and Ceramide together is quite safe if used with recommended concentrations. Niacinamide is a type of vitamin B that dissolves in water and comes from vitamin B3. It’s important for making two key energy molecules in our bodies, called NAD and NADP, along with their “charged” forms NADH and NADPH. These molecules are crucial for energy and repair processes in our cells, including those in our skin. Back in 1976, scientists first talked about how niacinamide could help fix the skin barrier in people with a condition called pellagra, which happens when you don’t have enough niacinamide or niacin. Ceramides on the other hand maintains skin health by repairing moisture barrier.

Niacinamide and ceramide together: Stunning combo for deadly skin problems

More recent studies found that niacinamide in combination with ceramides can help skin cells produce more fats, which are important for healthy and strong skin. When applied to the skin, this amazing combo helps increase these good fats in the top layer of the skin, keeping moisture in and making the skin less dry. It also helps reduce water loss from the skin, which is especially good for dry skin. Plus, people with a skin condition called rosacea noticed their skin got better hydrated and lost less water after using niacinamide.

– Helps repair and strengthen the skin barrier.

– Increases the production of fats and ceramides, important for healthy skin.

– Keeps moisture in the skin, reducing dryness.- Reduces water loss from the skin, preventing dehydration.

– Improves skin hydration, beneficial for conditions like rosacea.

The concentration of using niacinamide and Ceramide together

In beauty products, nicotinamide (another name for niacinamide) is typically used at concentrations between 4% and 5% to tackle signs of aging and uneven skin tone. Research has consistently demonstrated that products infused with nicotinamide can significantly reduce signs of aging, such as wrinkles, loss of elasticity, and discoloration, when compared to products lacking this ingredient.

Ceramide cream and cleanser have special ingredients like ceramide EOP, ceramide NP, cholesterol, and linoleic acid, which comes from safflower oil. They are mixed together in a very specific way – for every 3 parts of one ingredient, there’s 1 part of the other two. Getting this mix just right is key to making your skin barrier stronger and healthier.

Using niacinamide with ceramide together

5 definite reasons of using ceramides and niacinamide together

1- A well-structured skincare routine incorporating nicotinamide-ceramide can offer benefits similar to those of retinol-based treatments.

2-Moreover, combining nicotinamide with ceramides may enhance these effects. Additionally, applying nicotinamide-enriched products to areas with excess pigmentation can lead to noticeable skin brightening.

3- In fact, the efficacy of 4% nicotinamide in lightening the skin is nearly on par with the results achieved using 4% hydroquinone, a well-known skin lightening agent.

4- Effective in treatment of atopic dermatitis, rosacea and pellagra.

5- Repairs broken moisture barrier of the skin and hydrates it.

Final words

Nearly all skin types can use this combo to fight signs of ageing along with environmental pollutants. It is highly recommended to consult your dermatologist before adopting a skincare routine and always opt for solutions which are budget friendly and are always available.

What are some side effects of using ceramides and niacinamide together?

Using niacinamide and ceramides might cause issues for the liver or other parts of the body if used a lot over a long time. Studies with rats showed that too much nicotinamide could lead to big changes in their bodies and genes if they keep having it for a long time. However, when people put a cream with 10% nicotinamide on their skin, they didn’t feel any stinging, warmth, or irritation, even after using a 5% nicotinamide cream every day for 21 days. This means skin usually handles nicotinamide quite well when it’s used in amounts less than 5%. But, everyone’s skin is different, so if someone notices bad reactions after using it, they should talk to a doctor.

How often can i use niacinamide and ceramide together?

You can use this amazing combo twice daily, but it is very important to use dermatologist recommended sunscreen to avoide hyperpigmentation and other skin related issues.

What is the regimen of layering niacinamide and ceramide?

You can use it twice daily, but follow these steps

1- Wash your face

2- Dry it with a clean towel to avoid acne breakouts

3- layer your skin with niacinamide pea size and then apply ceramide cream

4- Or you can mix both in equal proportion on your palm and can gently apply it on your skin

5- If you are apply the combo in day, don’t forget to apply sunscreen


Saba Saeed

Saba Saeed

Saba Saeed M.phil in pharmaceutical sciences., is a Board-Certified pharmacist with research expertise in Dermatology, Fellow of the American research centre in drug development and discovery, and has been an international leader in developing microneedles for different skin conditions for over 15 years. She played an important role in developing insulin loaded microneedles and later proved effectiveness of micro-needling technique in various cosmetic and dermatology treatments. She pioneered an online consultation center regarding effectiveness of microneedling and dosage of various substances delivered via it. She provided online consultation to a number of men and women which helped them in making right decision for their skin.She also worked on novel drug delivery system i.e. mucoadhesive buccal patches for delivery of drugs with narrow therapeutic index. She is recently working on 3D-printing of drugs and loading of anti-diabetic drugs on microneedles with Dr. Sohail Muhammad Arshad (Dean Faculty of Pharmacy). She has contirbuted alot in serving needs of the community and is uplifting culture of safety and security. She provides online consultation on various health related concerns and you can book an appointment directly with her to inquire about related concerns.She also worked on novel drug delivery system i.e. mucoadhesive buccal patches for delivery of drugs with narrow therapeutic index. She is recently working on 3D-printing of drugs and loading of anti-diabetic drugs on microneedles with Dr. Sohail Muhammad Arshad (Dean Faculty of Pharmacy).She has contirbuted alot in serving needs oft he community and is uplifting culture of safety and security. She provides online consultation on various health related concerns and you can book an appointment directly with her to inquire about related concerns.

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