4 major challenges that make microneedling with growth factors a question mark.


Updated: 5 December 2023

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Microneedling with growth factors

Microneedling with growth factors is a breakthrough in skin care that’s transforming how we approach youthful, radiant skin with growth substancesextractedfrom humans. This simple yet powerful technique blends the gentle art of microneedling with the healing power of growth factors all in amazing patterns. It works by making tiny punctures on your skin via microneedling, which kickstarts your body’s natural healing process.

Microneedling with growth factors a complicated procedure.

Growth factors, usually taken from your own blood, are added to boost this healing, making your skin repair and renew itself faster. It’s an ideal choice for anyone looking to smooth out wrinkles, improve skin texture, and get that fresh, youthful glow. This guide will take you through everything you need to know about this easy, effective treatment and what it can do for your skin.

Table of Content
  1. Essentials of microneedling with growth factors
  2. Some cutting-Edge benefits of growth factors for skin
  3. Some major challenge of microneedling with growth factors.
    1. Precise Formulation:
    2. Manufacturing Factors.
    3. Bioengineering and Formulation
    4. Topical Delivery Systems
  4. Future Research
    1. How many sessions of microneedling with growth factors are needed for effective results.The microchannels created via needling provides a very narrow path for the growth substances to penetrate in the skin and it is not possible to get the results right after the procedure. You need to wait for prominent results as it needs 4-5 sessions for noticeable changes in your skin tone, complexion and texture.what is the cost of microneedling with growth factors The cost of microneedling with growth factors can vary significantly depending on various factors, including the geographic location, the provider's expertise, and the number of sessions required. Here's a general estimated cost range for microneedling with growth factors,Small Town or area the cost is around $200-$400. Whereas, in high end spa or clinic the price range is $1500- $2000. Please note that these are average price ranges, and actual costs may vary. It's essential to consult with local providers and obtain personalized quotes based on your specific needs and location. Additionally, multiple sessions may be recommended for optimal results, which can further influence the total cost of treatment.Is microneedling with growth factors worth it?Yes, micro needling with growth factors is totally worth it. The process is slow but long lasting. The results lasts longer with noticeable changes in the skin.what are the side effects of microneedling with growth factors? The side effects are related to formulation. The formulation of growth factors is very unstable and interacts with excipients which is risky. Thus, this procedure requires professionals who are experts in extracting the growth factors and then applying it within the specified time for maximum results. The side effects can be worse if the procedure is not properly carried out, it includes- Hyperpigmentation - wrinkled skin- Flaking of skin- multi-textured skin- Inflammation - Acnewhat is the after care of microneedling with growth substances?

Essentials of microneedling with growth factors

The exciting synergy between growth factors and microneedling presents a promising solution for combatting the telltale signs of skin aging. As we age, our skin undergoes transformations, from shifts in pigmentation and thinning to the emergence of fine lines and wrinkles. The magic lies in growth factors, acting as vital messengers that orchestrate cell growth, repair mechanisms, and the creation of the extracellular matrix (ECM).

On the other front, microneedling with growth factors delicately crafts controlled micro-punctures in the skin, igniting the production of collagen, fostering neovascularization thus improving blood circulation, and expediting the skin’s innate wound healing prowess. This dynamic combination offers a compelling avenue for achieving skin rejuvenation and effectively addressing the multifaceted aspects of aging skin. Here is a list of growth factors which are super beneficial for your skin.

Growth FactorBenefits for Skin
Epidermal Growth Factor (EGF)Stimulates cell growth, repairs damaged skin, reduces wrinkles, and promotes skin healing.
Transforming Growth Factor-Beta (TGF-B)Enhances collagen production, reduces inflammation, and improves skin elasticity.
Platelet-Derived Growth Factor (PDGF)Promotes tissue repair, accelerates wound healing, and helps with scar reduction.
Fibroblast Growth Factor (FGF)Stimulates the production of collagen and elastin, leading to firmer and more youthful skin.
Vascular Endothelial Growth Factor (VEGF)Improves blood circulation in the skin, aiding in nutrient delivery and overall skin health.
Insulin-Like Growth Factor (IGF)Supports cell growth and regeneration, contributing to smoother, healthier skin.
Keratinocyte Growth Factor (KGF)Encourages the growth of new skin cells and helps maintain the skin’s protective barrier.
Table-1: Best growth factors for microneedling

These growth factors play crucial roles in skin rejuvenation, promoting collagen synthesis, reducing signs of aging, and enhancing overall skin health.

Some cutting-Edge benefits of growth factors for skin

Benefits of microneedling with growth factors are countless, here are some highlighted benefits from improved skin texture to reduced pigmentation if performed to a certain specific depth.

Microneedling with growth factors
Growth factors Microneedling

Some major challenge of microneedling with growth factors.

Microneedling with Growth Factors (EGF) are a promising frontier in the realm of cosmetic anti-aging solutions. They play a pivotal role in stimulating the proliferation of fibroblasts and the synthesis of collagen in the skin. However, EGF faces certain challenges due to its inherent instability and substantial size when used in topical applications. To harness its potential effectively, several key considerations come into play.

Precise Formulation:

Achieving the right formulation conditions is imperative to prevent adverse interactions between growth factors and other components within the product. This is crucial for maintaining the stability of the formulation which has been applied on your skin and thus it is highly recommended to visit a nearby professional.

Manufacturing Factors.

The manufacturing process and subsequent storage conditions exert a significant impact on preserving the integrity of the growth factors because they are effectivewithina very narrow timeline. Specialized measures are essential to ensure its continued efficacy.

Bioengineering and Formulation

Employing bioengineering techniques and selecting compatible ingredients can amplify the therapeutic benefits of growth factors in cosmetic products. This is the biggest challenge as well because extraction and utilization of these growth substances cannot be carried out without the help of a specialist.

Topical Delivery Systems

The use of topical drug delivery systems that both immobilize and shield growth substances is paramount. Nanoparticulate systems facilitate the passage of growth factors through the skin’s outermost layer, but it is very complicated. This is the very reason the results are visible after 4-5 sessions because the penetration is slow via microneedling and it is definitely not the fastest delivery channel.

Disclaimer

There is high chance of side effects with the growth factors and it is highly recommended to carryout the procedure under supervision of a specialist. Do not try “Microneedling with growth factors” at home.

Future Research

Ongoing research endeavors are essential for a deeper understanding of Growth factors interactions within cosmetic formulations and its physical characteristics. This knowledge will pave the way for the creation of enduring and user-friendly anti-aging products.In essence, EGF holds immense promise for combating the signs of aging, but meticulous formulation, manufacturing practices, and advanced delivery methods are prerequisites for effectively unlocking its potential in cosmetic products.

How many sessions of microneedling with growth factors are needed for effective results.

The microchannels created via needling provides a very narrow path for the growth substances to penetrate in the skin and it is not possible to get the results right after the procedure. You need to wait for prominent results as it needs 4-5 sessions for noticeable changes in your skin tone, complexion and texture.

what is the cost of microneedling with growth factors

The cost of microneedling with growth factors can vary significantly depending on various factors, including the geographic location, the provider’s expertise, and the number of sessions required. Here’s a general estimated cost range for microneedling with growth factors,Small Town or area the cost is around $200-$400. Whereas, in high end spa or clinic the price range is $1500- $2000.
Please note that these are average price ranges, and actual costs may vary. It’s essential to consult with local providers and obtain personalized quotes based on your specific needs and location. Additionally, multiple sessions may be recommended for optimal results, which can further influence the total cost of treatment.

Is microneedling with growth factors worth it?

Yes, micro needling with growth factors is totally worth it. The process is slow but long lasting. The results lasts longer with noticeable changes in the skin.

what are the side effects of microneedling with growth factors?

The side effects are related to formulation. The formulation of growth factors is very unstable and interacts with excipients which is risky. Thus, this procedure requires professionals who are experts in extracting the growth factors and then applying it within the specified time for maximum results. The side effects can be worse if the procedure is not properly carried out, it includes
– Hyperpigmentation
– wrinkled skin
– Flaking of skin
– multi-textured skin
– Inflammation
– Acne

what is the after care of microneedling with growth substances?

Growth factors microneedling is known for its unstability and short shelf life and the chances of interaction with other skincare products are high. Follow simple step guide to takecare of your skin after microneedling with growth factors.
– Do not apply harsh cosmetics/chemicals on your skin atleast for 1 week
– Do apply sunscreen which is recommended by your skin specialist
– Do not wash immediately after the procedure or wash with lukewarm water after 8-10hrs.
– Immediately consult dermatologist if the inflammation didn’t go away after 24-44hrs


Saba Saeed

Saba Saeed

Saba Saeed M.phil in pharmaceutical sciences., is a Board-Certified pharmacist with research expertise in Dermatology, Fellow of the American research centre in drug development and discovery, and has been an international leader in developing microneedles for different skin conditions for over 15 years. She played an important role in developing insulin loaded microneedles and later proved effectiveness of micro-needling technique in various cosmetic and dermatology treatments. She pioneered an online consultation center regarding effectiveness of microneedling and dosage of various substances delivered via it. She provided online consultation to a number of men and women which helped them in making right decision for their skin.She also worked on novel drug delivery system i.e. mucoadhesive buccal patches for delivery of drugs with narrow therapeutic index. She is recently working on 3D-printing of drugs and loading of anti-diabetic drugs on microneedles with Dr. Sohail Muhammad Arshad (Dean Faculty of Pharmacy). She has contirbuted alot in serving needs of the community and is uplifting culture of safety and security. She provides online consultation on various health related concerns and you can book an appointment directly with her to inquire about related concerns.She also worked on novel drug delivery system i.e. mucoadhesive buccal patches for delivery of drugs with narrow therapeutic index. She is recently working on 3D-printing of drugs and loading of anti-diabetic drugs on microneedles with Dr. Sohail Muhammad Arshad (Dean Faculty of Pharmacy).She has contirbuted alot in serving needs oft he community and is uplifting culture of safety and security. She provides online consultation on various health related concerns and you can book an appointment directly with her to inquire about related concerns.

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